You can open the Profile Statistics window by clicking the Statistics button in the Profile Table window.
Statistics are shown for each RGB channel in the selected layer. The window calculates the minimum, maximum, average, weighted average, and weighted average summary statistics for the sample gray values along the profile.
Weighted average is the most accurate measure of central tendency among sample points. The weight of a sample gray value is the ratio of the length of a sample interval over the total distance of all the sample intervals.
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